Whole Body Cryotherapy (WBC) is the therapeutic application of extreme cold dry air, usually down to -110°C, that alleviates inflammation and pain. When the body is exposed to acute cold temperatures, the body’s natural thermoregulatory system activates to maintain body heat. This process secretes neurochemicals and hormones chief among which are dopamine, norepinephrine, and serotonin. The initial phase of vasoconstriction is induced by dopamine (precursor to NE), norepinephrine, and serotonin. The elevated levels of these neurochemicals allow the subjects to feel energized, and happier and when the circadian clock hits, produce melatonin, which helps with sleep.